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Phenotypes Associated with This Genotype
Genotype
MGI:5314415
Allelic
Composition		 Crhr1tm1Klee/Crhr1+
Tg(MECP2)1Hzo/0
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEv * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crhr1tm1Klee mutation (1 available); any Crhr1 mutation (28 available)
Tg(MECP2)1Hzo mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal anxiety-related response ( J:181213 )
• anxiety-like behavior is reduced compared to single Tg(MECP2)1Hzo hemizygous mice, with double mutants being less anxious in the elevated plus maze and the light/dark box

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory