Phenotypes Associated with This Genotype

Genotype
MGI:5314803

• Allelic Composition: Lhx8^tm1Vpa/Lhx8^tm2.1Vpa; Tg(Chat-cre)GM24Gsat/0
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal striatum morphology ( J:182013 )

• cholinergic striatal interneurons are severely reduced in the striatum

abnormal neuron morphology ( J:182013 )

• small but statistically significant reduction in the nuclear size of ChAT+ neurons in the striatum

abnormal neuron differentiation ( J:182013 )

• potential cholinergic interneurons lose their cholinergic markers and develop into GABAergic interneurons

abnormal brain interneuron morphology ( J:182013 )

• cholinergic striatal interneurons are severely reduced in the striatum

abnormal GABAergic neuron morphology ( J:182013 )

• potential cholinergic interneurons lose their cholinergic markers and develop into GABAergic interneurons

abnormal cholinergic neuron morphology ( J:182013 )

• loss of cholinergic neurons in the striatum

cellular

abnormal neuron differentiation ( J:182013 )

• potential cholinergic interneurons lose their cholinergic markers and develop into GABAergic interneurons