Phenotypes Associated with This Genotype

Genotype
MGI:5316845

• Allelic Composition: Tg(PAX6)77Ndha/Tg(PAX6)77Ndha
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

vision/eye phenotype ( J:188155 )

N • no thickening of the retinal pigment epithelium

abnormal lens morphology ( J:137605 )

• lens defects do not appear until after E12.5

• retinal attachment to the lens develops as the vitreous disappears

microphthalmia ( J:137605 )

• eyes are significantly smaller by E14.5

abnormal posterior eye segment morphology ( J:137605 )

abnormal optic chiasm morphology ( J:137605 )

• fewer retinal ganglion cell axons reach the optic chiasma

• reduction in contralateral projection of retinal ganglion cell axons

abnormal retina morphology ( J:137605 )

• retinal attachment to the lens develops as the vitreous disappears

• rosette-like structures in the retina at 4 days of age

abnormal retina pigment epithelium morphology ( J:137605 )

• extends along the optic stalk

abnormal retina neuronal layer morphology ( J:137605 )

• extends along the optic stalk

disorganized retina ganglion layer ( J:137605 )

• less structured at E18.5

• retinal ganglion cell axons follow a more erratic course toward the optic nerve

• fewer retinal ganglion cell axons reach the optic chiasma

retina fold ( J:137605 )

• peripheral retina folds back toward the vitreous chamber

abnormal vitreous body morphology ( J:137605 )

• vitreous chamber almost completely disappears by 2 days of age

• hyperplastic vitreous at E14.5

pigmentation

abnormal retina pigment epithelium morphology ( J:137605 )

• extends along the optic stalk

nervous system

abnormal optic chiasm morphology ( J:137605 )

• fewer retinal ganglion cell axons reach the optic chiasma

• reduction in contralateral projection of retinal ganglion cell axons