Phenotypes Associated with This Genotype

Genotype
MGI:5317921

• Allelic Composition: Noto^{tm2.1(Foxj1)Gos}/Noto^{tm2.1(Foxj1)Gos}
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal motile primary cilium physiology ( J:182741 )

• decrease in directional movement in the nodal flow

• however, unlike in mice homozygous for Noto ^tm1Gos nodal cilia are motile

abnormal left-right axis patterning ( J:182741 )

• randomized expression of laterality genes

abnormal primitive node morphology ( J:182741 )

• variable size

• abnormal expression patterns of genes delineating the node

abnormal motile primary cilium morphology ( J:182741 )

• partial restoration of cilia length at the mid to late head fold stage compared to mice homozygous for Noto ^tm1Gos

• unlike in homozygous null mice, microtubule defects are not detected

abnormal embryonic cilium location or orientation ( J:182741 )

• position of cilia emergence is randomized rather than polarized towards the posterior end of the nodal cells

limbs/digits/tail

short tail ( J:182741 )

kinked tail ( J:182741 )

cellular

abnormal motile primary cilium morphology ( J:182741 )

• partial restoration of cilia length at the mid to late head fold stage compared to mice homozygous for Noto ^tm1Gos

• unlike in homozygous null mice, microtubule defects are not detected

abnormal embryonic cilium location or orientation ( J:182741 )

• position of cilia emergence is randomized rather than polarized towards the posterior end of the nodal cells

abnormal motile primary cilium physiology ( J:182741 )

• decrease in directional movement in the nodal flow

• however, unlike in mice homozygous for Noto ^tm1Gos nodal cilia are motile