Phenotypes Associated with This Genotype

Genotype
MGI:5320495

• Allelic Composition: Glmn^{Gt(OST109778)Lex}/Glmn^{Gt(OST109778)Lex}
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:184206 )

• mice die between E10.5 and E12.5

embryo

disorganized yolk sac vascular plexus ( J:184206 )

• at E9.5, yolk sacs fail to form an organized vascular network and blood cells moved slowly compared to in wild-type mice

incomplete embryo turning ( J:184206 )

• at E9.5

embryonic growth retardation ( J:184206 )

• at E9.5

abnormal head mesenchyme morphology ( J:184206 )

• at E9.5, head mesenchyme exhibits reduced cellularity and cystic degeneration unlike in wild-type mice

delayed neural tube closure ( J:184206 )

• at E9.5

cardiovascular system

disorganized yolk sac vascular plexus ( J:184206 )

• at E9.5, yolk sacs fail to form an organized vascular network and blood cells moved slowly compared to in wild-type mice

pericardial effusion ( J:184206 )

• at E9.5

hemorrhage ( J:184206 )

• at E9.5, mice exhibit blood cell accumulation in the head and trunk region

nervous system

delayed neural tube closure ( J:184206 )

• at E9.5

cellular

increased apoptosis ( J:184206 )

• in some neuroepithelial and mesenchymal cells in the head at E9.5

homeostasis/metabolism

pericardial effusion ( J:184206 )

• at E9.5

growth/size/body

embryonic growth retardation ( J:184206 )

• at E9.5

abnormal head mesenchyme morphology ( J:184206 )

• at E9.5, head mesenchyme exhibits reduced cellularity and cystic degeneration unlike in wild-type mice