Phenotypes Associated with This Genotype

Genotype
MGI:5320665

• Allelic Composition: Frzb^tm1.1Fplu/Frzb^tm1.1Fplu
• Genetic Background: involves: CD-1 * Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal femur morphology ( J:184281 )

• increase in midfemoral bone surface area at 10 weeks of age in male and female mice

abnormal bone structure ( J:184281 )

increased bone mineral content ( J:184281 )

• higher cortical mineral content at 10, 16 and 20 weeks of age in male and female mice

increased bone mineral density ( J:184281 )

• higher cortical mineral density at 16 and 20 weeks of age in the tibia of male and female mice

increased compact bone thickness ( J:184281 )

• at 10, 16 and 20 weeks of age in male and female mice

abnormal skeleton physiology ( J:184281 )

abnormal bone remodeling ( J:184281 )

• enhanced anabolic effect (increase in periosteal bone volume) compared to wild-type controls

• at a strain rate of about 17,500 muepsilon/second a significant increase in bone volume is seen in ulnas from mutant mice but not from wild-type mice

increased bone strength ( J:184281 )

• similar loads result in lower strain indicating that the bones are stiffer

hematopoietic system

decreased hematocrit ( J:184281 )

limbs/digits/tail

abnormal femur morphology ( J:184281 )

• increase in midfemoral bone surface area at 10 weeks of age in male and female mice