Phenotypes Associated with This Genotype

Genotype
MGI:5320666

• Allelic Composition: Frzb^tm1.1Fplu/Frzb^tm1.1Fplu
• Genetic Background: B6J.Cg-Frzb^tm1.1Fplu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal skeleton physiology ( J:184281 )

• loss of sulfated proteoglycans from articular cartilage is increased 7 days after intraarticular papain injection, 21 days after collagenase injection, and 7 days after mBSA injection

• however, inflammatory and fibrotic changes are similar to controls and no increase in the incidence of spontaneous osteoarthritis of the knee is detected

homeostasis/metabolism

increased physiological sensitivity to xenobiotic ( J:184281 )

• loss of sulfated proteoglycans from articular cartilage is increased 7 days after intraarticular papain injection, 21 days after collagenase injection, and 7 days after mBSA injection

• however, inflammatory and fibrotic changes are similar to controls