Phenotypes Associated with This Genotype

Genotype
MGI:5426233

• Allelic Composition: Lepr^tm1Jke/Lepr^tm1Jke; Tg(Pomc1-cre)16Lowl/0
• Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:184572 )

N • mice exhibit normal circulating glucagon levels in the fed and carbohydrate-refed state

increased circulating leptin level ( J:184572 )

• compared with wild-type mice

decreased circulating cholesterol level ( J:184572 )

• compared with Lepr^tm1Jke homozygotes

increased circulating cholesterol level ( J:184572 )

• compared with wild-type mice

decreased circulating triglyceride level ( J:184572 )

• compared with Lepr^tm1Jke homozygotes

increased circulating triglyceride level ( J:184572 )

• compared with wild-type mice

decreased carbon dioxide production ( J:184572 )

• compared with wild-type mice

increased carbon dioxide production ( J:184572 )

• compared with Lepr^tm1Jke homozygotes

decreased oxygen consumption ( J:184572 )

• compared with wild-type mice

increased oxygen consumption ( J:184572 )

• compared with Lepr^tm1Jke homozygotes

increased respiratory quotient ( J:184572 )

• compared with wild-type mice

abnormal glucose homeostasis ( J:184572 )

• mice exhibit normal basal glucose turnover compared with Lepr^tm1Jke homozygotes

• insulin-stimulated glucose disposal is impaired compared to in wild-type mice

• however, mice exhibit normal circulating glucose levels at 6, 8 and 12 weeks

increased insulin secretion ( J:184572 )

• in the pancreas compared with wild-type mice

decreased circulating glucose level ( J:184572 )

• compared with Lepr^tm1Jke homozygotes

decreased circulating insulin level ( J:184572 )

• at 8 and 12 weeks compared with Lepr^tm1Jke homozygotes

increased circulating insulin level ( J:184572 )

• compared with wild-type mice

increased insulin sensitivity ( J:184572 )

• compared with Lepr^tm1Jke homozygotes

decreased liver triglyceride level ( J:184572 )

• compared with Lepr^tm1Jke homozygotes

increased liver triglyceride level ( J:184572 )

• compared with wild-type mice

growth/size/body

decreased body weight ( J:184572 )

• in male mice after 12 weeks compared with Lepr^tm1Jke homozygotes

obese ( J:184572 )

• in male mice between 4 and 12 weeks less severe after 12 weeks compared with wild-type mice

• in female mice

behavior/neurological

abnormal eating behavior ( J:184572 )

• compared with wild-type mice

hyperactivity ( J:184572 )

• during the dark phase compared with wild-type mice

adipose tissue

decreased total body fat amount ( J:184572 )

• in male mice at 20 weeks compared with Lepr^tm1Jke homozygotes

increased total body fat amount ( J:184572 )

• in male mice at 12 and 20 weeks compared with wild-type mice

endocrine/exocrine glands

increased insulin secretion ( J:184572 )

• in the pancreas compared with wild-type mice

liver/biliary system

decreased liver triglyceride level ( J:184572 )

• compared with Lepr^tm1Jke homozygotes

increased liver triglyceride level ( J:184572 )

• compared with wild-type mice