Phenotypes Associated with This Genotype

Genotype
MGI:5426907

• Allelic Composition: Rgs11^tm1Lex/Rgs11^tm1Lex; Rgs7^tm1Cjch/Rgs7^tm1Cjch
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Rgs7^tm1Cjch/Rgs7^tm1Cjch Rgs11^tm1Lex/Rgs11^tm1Lex mice have no ERG b-waves and contain ultrastructural defects in the retinal outer plexiform layer

mortality/aging

mortality/aging ( J:184922 )

N • normal viability

reproductive system

reproductive system phenotype ( J:184922 )

N • normal fertility

vision/eye

abnormal retina outer plexiform layer morphology ( J:184922 )

• fewer triads per spherule compared to in wild-type mice

• fewer spherules with ribbons compared to in wild-type mice

abnormal cone electrophysiology ( J:184922 )

• absent b-wave under scotopic and photopic conditions

abnormal rod electrophysiology ( J:184922 )

• absent b-wave under scotopic and photopic conditions