Phenotypes for Grm8 MGI:5427829 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Grm8^tm1Dgen/Grm8^tm1Dgen
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grm8^tm1Dgen mutation (2 available); any Grm8 mutation (68 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal locomotor behavior ( J:82809 )

• homozygous mutant animals displayed a statistically significant increase in total distance traveled in the open field test, relative to wild-type animals

nervous system

decreased prepulse inhibition ( J:82809 )

• homozygous mutant animals displayed a statistically significant decrease in Prepulse Inhibition (PPI) with a 100dB prepulse

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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