Phenotypes Associated with This Genotype

Genotype
MGI:5427923

• Allelic Composition: Tg(Col1a1-Mir34c)#Kry/0
• Genetic Background: B6.Cg-Tg(Col1a1-Mir34c)#Kry

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Decreased bone mass in Tg(Col1a1-Mir34c)#Kry/0 mice

cellular

abnormal osteoblast physiology ( J:185130 )

• decreased osteoblast activity

decreased osteoblast proliferation ( J:185130 )

• decreased osteoblast proliferation compared with controls

skeleton

skeleton phenotype ( J:185130 )

N • osteoclast surface and bone resorption are normal

abnormal osteoblast physiology ( J:185130 )

• decreased osteoblast activity

decreased osteoblast proliferation ( J:185130 )

• decreased osteoblast proliferation compared with controls

decreased osteoblast cell number ( J:185130 )

decreased bone mass ( J:185130 )

abnormal skeleton development ( J:185130 )

• decreased bone formation rate