Phenotypes Associated with This Genotype

Genotype
MGI:5427982

• Allelic Composition: Dhx36^tm1.2Pmt/Dhx36^tm1.2Pmt; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: 129P2/Ola * 129S4/SvJaeSor * C57BL/6 * C57BL/10 * CBA/Ca

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

thymus hypoplasia ( J:185179 )

• without affecting architecture

enlarged spleen ( J:185179 )

• in adult mice

abnormal erythropoiesis ( J:185179 )

• mice exhibit an increase in ProE and Ery.A fractions but a decrease in Ery.B and Ery.C in the bone marrow compared with control mice

• mice exhibit an increase in ProE and Ery.A fractions but a decrease in Ery.C in the spleen compared with control mice

• early erythropoiesis is partially blocked in association with a cell cycle defect

• proerythroblast exhibit reduced proliferation compared with control cells

• however, proerythroblast apoptosis rates are normal

anemia ( J:185179 )

• intrinsic as determined by bone marrow transplantation

hemolytic anemia ( J:185179 )

decreased granulocyte monocyte progenitor cell number ( J:185179 )

• decrease in the granulocyte macrophage progenitor (GMP) cells in the bone marrow

abnormal proerythroblast morphology ( J:185179 )

• ProE cells are increased 3.6- and 74-fold in the bone marrow and spleen compared with control mice

decreased erythroblast number ( J:185179 )

• in the bone marrow

increased erythroblast number ( J:185179 )

• 4.7-fold in the spleen

decreased erythrocyte cell number ( J:185179 )

decreased hemoglobin content ( J:185179 )

increased mean corpuscular volume ( J:185179 )

spherocytosis ( J:185179 )

reticulocytosis ( J:185179 )

• secondary

increased hematopoietic stem cell number ( J:185179 )

• early long and short term hematopoietic stem cells are increased compared to in control mice

• however, the number of lymphoid-primed multipotent progenitors is normal and the increased in hematopoietic stem cells disappears in the alter stages of differentiation

increased megakaryocyte-erythroid progenitor cell number ( J:185179 )

• increase in the megakaryocyte-erythroid progenitor (MEP) cells in the spleen

intermingled spleen red and white pulp ( J:185179 )

abnormal erythrocyte physiology ( J:185179 )

• reduced half-life

liver/biliary system

enlarged liver ( J:185179 )

• in adult mice

pale liver ( J:185179 )

renal/urinary system

pale kidney ( J:185179 )

cellular

abnormal cell cycle ( J:185179 )

• proerythroblast exhibit reduced proliferation compared with control cells

integument

pallor ( J:185179 )

• at birth

immune system

thymus hypoplasia ( J:185179 )

• without affecting architecture

enlarged spleen ( J:185179 )

• in adult mice

intermingled spleen red and white pulp ( J:185179 )

endocrine/exocrine glands

thymus hypoplasia ( J:185179 )

• without affecting architecture

growth/size/body

enlarged liver ( J:185179 )

• in adult mice

enlarged spleen ( J:185179 )

• in adult mice