Phenotypes Associated with This Genotype

Genotype
MGI:5428320

• Allelic Composition: Tg(RP11-111A8)1Zim/0
• Genetic Background: involves: CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:150615 )

N • mice exhibit normal anxiety- and depression-related behaviors

enhanced behavioral response to addictive substance ( J:150615 )

• mice exhibit a greater increased in locomotor effects induced by phencyclidine compared with wild-type mice

increased grooming behavior ( J:150615 )

impaired coordination ( J:150615 )

• on a rotarod or a beam-walking test

nervous system

decreased prepulse inhibition ( J:150615 )

• however, treatment with haloperidol restores prepulse inhibition

taste/olfaction

impaired olfaction ( J:150615 )

• mice fail to discriminate between urine and water spots unlike wild-type mice