Phenotypes Associated with This Genotype

Genotype
MGI:5429230

• Allelic Composition: Cdk7^{Gt(D032B11)1.1Wrst}/Cdk7^{Gt(D032B11)1.1Wrst}; Tg(KRT5-cre)1Tak/0
• Genetic Background: involves: 129S2/SvPas * C3H * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:183925 )

• die between P1 and P4

integument

sparse hair ( J:183925 )

• widespread lack of hair

decreased hair follicle number ( J:183925 )

• severe decrease in hypoplastic epidermal regions

abnormal epidermal layer morphology ( J:183925 )

• the epidermis shows scattered hyperplastic and hypoplastic regions

• cells in hyperplastic regions continue to express Cdk7 whiles those in hypoplastic regions do not

abnormal epidermis suprabasal layer morphology ( J:183925 )

• hyperplastic regions show an expansion of keratin K5 expressing cells into the suprabasal layer and disorganization of these layers

thin epidermis suprabasal layer ( J:183925 )

• in hypoplastic regions

abnormal keratinocyte morphology ( J:183925 )

• hyperplastic regions show an expansion of keratin K5 expressing cells into the suprabasal layer and disorganization of these layers

scaly skin ( J:183925 )

abnormal skin development ( J:183925 )

• hypoplastic epidermal regions show delayed development and an abnormal differentiation pattern

growth/size/body

decreased birth body size ( J:183925 )