Phenotypes Associated with This Genotype

Genotype
MGI:5429767

• Allelic Composition: Rdh10^{tm1d(KOMP)Wtsi}/Rdh10^{tm1d(KOMP)Wtsi}
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * C57BL/6N
• Cell Lines: EPD0149_1_D08

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:185330 )

• viable embryos are not found after E10.5

embryo

abnormal embryo turning ( J:185330 )

• defects in axial turning, most apparent at E9.5

embryonic growth arrest ( J:185330 )

• cease growth and axis extension around E9.25

embryonic growth retardation ( J:185330 )

• defects in embryo growth

decreased embryo size ( J:185330 )

decreased somite size ( J:185330 )

• small somites

cardiovascular system

failure of heart looping ( J:185330 )

• fail to undergo normal looping and chamber formation

abnormal heart tube morphology ( J:185330 )

• edemic hearts

hearing/vestibular/ear

small otic vesicle ( J:185330 )

• tiny

homeostasis/metabolism

abnormal vitamin A metabolism ( J:185330 )

• dramatic reduction in retinoic acid signaling

growth/size/body

embryonic growth retardation ( J:185330 )

• defects in embryo growth

decreased embryo size ( J:185330 )