Phenotypes Associated with This Genotype

Genotype
MGI:5429769

• Allelic Composition: Rdh10^trex/Rdh10^trex
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal pharyngeal arch morphology ( J:185330 )

• at E9.5, arches posterior to the second arch are either absent or fused to the second arch

abnormal fourth pharyngeal arch morphology ( J:185330 )

• absent or fused to the second arch

abnormal sixth pharyngeal arch morphology ( J:185330 )

• absent or fused to the second arch

abnormal third pharyngeal arch morphology ( J:185330 )

• absent or fused to the second arch

absent pharyngeal arches ( J:185330 )

• absence of posterior arches is evident at E10.5

absent fourth pharyngeal arch ( J:185330 )

absent sixth pharyngeal arch ( J:185330 )

absent third pharyngeal arch ( J:185330 )

fused pharyngeal arches ( J:185330 )

• third and more posterior pharyngeal arches are absent or fused to the second arch

small forelimb buds ( J:185330 )

• decrease in forelimb bud size at E10.5

cardiovascular system

abnormal heart looping ( J:185330 )

• looping defects at E9.5

hearing/vestibular/ear

abnormal otic vesicle morphology ( J:185330 )

• usually small, duplicated and displaced posteriorly at E9.5

small otic vesicle ( J:185330 )

• usually small

homeostasis/metabolism

cardiac edema ( J:185330 )

• cardiac edema at E9.5

abnormal vitamin A metabolism ( J:185330 )

• dramatic reduction in retinoic acid signaling

limbs/digits/tail

small forelimb buds ( J:185330 )

• decrease in forelimb bud size at E10.5

craniofacial

abnormal pharyngeal arch morphology ( J:185330 )

• at E9.5, arches posterior to the second arch are either absent or fused to the second arch

abnormal fourth pharyngeal arch morphology ( J:185330 )

• absent or fused to the second arch

abnormal sixth pharyngeal arch morphology ( J:185330 )

• absent or fused to the second arch

abnormal third pharyngeal arch morphology ( J:185330 )

• absent or fused to the second arch

absent pharyngeal arches ( J:185330 )

• absence of posterior arches is evident at E10.5

absent fourth pharyngeal arch ( J:185330 )

absent sixth pharyngeal arch ( J:185330 )

absent third pharyngeal arch ( J:185330 )

fused pharyngeal arches ( J:185330 )

• third and more posterior pharyngeal arches are absent or fused to the second arch