Phenotypes Associated with This Genotype

Genotype
MGI:5431550

• Allelic Composition: Anxa1^tm1Rjf/Anxa1^tm1Rjf
• Genetic Background: involves: BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

weight loss ( J:142735 )

• more pronounced weight loss than in controls within 3 days of treatment with dextran sodium sulfate to induce colitis

• no improvement in body weight in the 7 days following treatment

digestive/alimentary system

abnormal intestinal epithelium morphology ( J:142735 )

• epithelial loss continues after the end of dextran sodium sulfate treatment

abnormal colon morphology ( J:142735 )

• colon weight to weight ratio is increased about 18% after 7 days of dextran sodium sulfate treatment

increased susceptibility to induced colitis ( J:142735 )

• more histological injury than in controls

• severity of disease remains elevated during the course of dextran sodium sulfate treatment compared to controls

• more rectal bleeding than in controls

• no disease improvement until 7 days after the end of dextran sodium sulfate treatment

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:142735 )

• 25% mortality when dextran sodium sulfate treatment is ended compared to zero mortality in controls

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:142735 )

• 25% mortality when dextran sodium sulfate treatment is ended compared to zero mortality in controls

immune system

increased susceptibility to induced colitis ( J:142735 )

• severity of disease remains elevated during the course of dextran sodium sulfate treatment compared to controls

• more rectal bleeding than in controls

• more histological injury than in controls

• no disease improvement until 7 days after the end of dextran sodium sulfate treatment