Phenotypes for Csf2 Il3 MGI:5431917 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Csf2^tm1Mlg/Csf2^tm1Mlg Il3^tm1Glli/Il3^tm1Glli
Genetic Background	B6.129S2-Csf2^tm1Mlg Il3^tm1Glli

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csf2^tm1Mlg mutation (1 available); any Csf2 mutation (33 available)
Il3^tm1Glli mutation (1 available); any Il3 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:145518 )

• large lymphoid aggregates surround and penetrate many islets

• islets are reduced in size

decreased pancreatic beta cell number ( J:145518 )

• reduced number of insulin secreting beta cells

homeostasis/metabolism

hyperglycemia ( J:145518 )

• fasting hyperglycemia in most but not all 8 month old mice

• significantly increased peak blood sugar after glucose challenge

impaired glucose tolerance ( J:145518 )

• significantly increased peak blood sugar after glucose challenge

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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