Phenotypes Associated with This Genotype

Genotype
MGI:5432105

• Allelic Composition: Grin2b^tm1Mony/Grin2b^tm1Mony; Tg(Camk2a-Grin2c/itTA)12Rsp/0; Tg(tetO-cre)LC1Bjd/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:186311 )

N • mice exhibit normal motor coordination and spatial reference memory acquisition in a Morris Water maze

abnormal spatial learning ( J:186311 )

• mice exhibit impaired spatial reversal learning compared with control mice

abnormal spatial working memory ( J:186311 )

• mice exhibit a small impairment in spatial working memory in an enclosed T maze compared with control mice

• less so than Grin2b^tm1Mony/Grin2b^tm1Mony Tg(Camk2a-cre)1Gsc mice

decreased anxiety-related response ( J:186311 )

• less so than Grin2b^tm1Mony/Grin2b^tm1Mony Tg(Camk2a-cre)1Gsc mice

hyperactivity ( J:186311 )

• less so than Grin2b^tm1Mony/Grin2b^tm1Mony Tg(Camk2a-cre)1Gsc mice

nervous system

abnormal excitatory postsynaptic currents ( J:186311 )

• in response to the Grin2b antagonist ifenprodil, mice fail to exhibit a strong reduction in NMDA excitatory postsynaptic currents and faster decay kinetics compared with control mice

abnormal NMDA-mediated synaptic currents ( J:186311 )

• in response to the Grin2b antagonist ifenprodil, mice fail to exhibit a strong reduction in NMDA excitatory postsynaptic currents and faster decay kinetics compared with control mice