Phenotypes Associated with This Genotype

Genotype
MGI:5432397

• Allelic Composition: Myh9^tm1.1Gac/Myh9^tm1.1Gac; Tg(NPHS2-cre)295Lbh/0
• Genetic Background: involves: 129 * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

renal/urinary system phenotype ( J:173971 )

N • surprisingly, mice are viable and do not develop overt chronic kidney disease up to 9 months of age

N • no excessive proteinuria at 1-9 months of age relative to control mice

N • normal urine albumin/creatinine ratios at 3-9 months of age relative to control mice

albuminuria ( J:173971 )

• at 3, 4, and 6 weeks after adriamycin injection, mice develop significantly more albuminuria than similarly-treated control mice

fused podocyte foot processes ( J:173971 )

• after adriamycin injection, mice exhibit patches of foot process fusion, unlike similarly-treated control mice

podocyte foot process effacement ( J:173971 )

• after adriamycin injection, mice exhibit patches of severe foot process effacement, unlike similarly-treated control mice

podocyte microvillus transformation ( J:173971 )

• after adriamycin injection, mice exhibit evidence of pseudovillous transformation, unlike similarly-treated control mice

increased renal glomerulus basement membrane thickness ( J:173971 )

• after adriamycin injection, mice exhibit thickening of the basement membrane in some glomerular loops, unlike similarly-treated control mice

glomerulosclerosis ( J:173971 )

• at 6 weeks after adriamycin injection, mice develop focal and segmental glomerulosclerosis ranging from mild segmental sclerosis to severe global sclerosis, unlike similarly-treated control mice which develop foci of mild sclerosis but no globally sclerotic glomeruli

renal cast ( J:173971 )

• at 6 weeks after adriamycin injection, mice exhibit numerous proteinaceous casts, unlike similarly-treated control mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:173971 )

N • no excessive proteinuria at 1-9 months of age relative to control mice

N • normal urine albumin/creatinine ratios at 3-9 months of age relative to control mice

N • normal serum creatinine and BUN levels at 9 months of age relative to control mice

albuminuria ( J:173971 )

• at 3, 4, and 6 weeks after adriamycin injection, mice develop significantly more albuminuria than similarly-treated control mice

increased susceptibility to injury ( J:173971 )

• following injection with doxorubicin hydrochloride (adriamycin; 15 ug/g) to induce kidney podocyte injury, 9-11 month old mice develop severe proteinuria and glomerulosclerosis, unlike similarly-treated control mice

growth/size/body

growth/size/body region phenotype ( J:173971 )

N • normal body weight at 9 months of age relative to control mice

cardiovascular system

cardiovascular system phenotype ( J:173971 )

N • no significant difference in tail cuff blood pressure at 11-12 months of age relative to control mice