Phenotypes Associated with This Genotype

Genotype
MGI:5432560

• Allelic Composition: Lama5^tm2Jhm/Lama5^tm1Jhm; Tg(NPHS2-cre)295Lbh/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

increased urine protein level ( J:185850 )

• animals show mild proteinuria early in life (3 weeks), and progress to the nephrotic range of disease

hematuria ( J:185850 )

• observed with age

tubulointerstitial nephritis ( J:185850 )

abnormal kidney morphology ( J:185850 )

• yellowing of the kidneys is observed with age

podocyte foot process effacement ( J:185850 )

abnormal renal glomerulus basement membrane morphology ( J:185850 )

• increased thickness, a moth-eated appearance and irregular contours with frequent subepithelial outpocketings are observed at late disease stages

increased renal glomerulus basement membrane thickness ( J:185850 )

expanded mesangial matrix ( J:185850 )

• observed at late stages of disease

glomerulosclerosis ( J:185850 )

• observed at late stages of disease

homeostasis/metabolism

increased circulating cholesterol level ( J:185850 )

• observed with age

decreased circulating serum albumin level ( J:185850 )

• observed with age

edema ( J:185850 )

• mice become edematous with age

increased urine protein level ( J:185850 )

• animals show mild proteinuria early in life (3 weeks), and progress to the nephrotic range of disease

hematuria ( J:185850 )

• observed with age

immune system

tubulointerstitial nephritis ( J:185850 )