Phenotypes Associated with This Genotype

Genotype
MGI:5433019

• Allelic Composition: Fads1^{Gt(IST11525H2)Tigm}/Fads1⁺
• Genetic Background: C57BL/6-Fads1^{Gt(IST11525H2)Tigm}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased prostaglandin level ( J:186265 )

• mice fed a diet lacking arachidonic acid exhibit an intermediate reduction in PGE2 levels in the colonic mucosa, small intestine mucosa and lung compared with wild-type and homozygous mice

increased prostaglandin level ( J:186265 )

• mice fed a diet lacking arachidonic acid exhibit an intermediate increase in PGE1 levels in the colonic mucosa, small intestine mucosa and lung compared with wild-type and homozygous mice

immune system

decreased interferon-gamma secretion ( J:186265 )

• from cultured and stimulated T cells and antibody presenting cells of mice fed a diet lacking arachidonic acid

decreased tumor necrosis factor secretion ( J:186265 )

• from cultured and stimulated T cells and antibody presenting cells of mice fed a diet lacking arachidonic acid

digestive/alimentary system

abnormal enterocyte proliferation ( J:186265 )

• mice fed a diet lacking arachidonic acid exhibit an intermediate decrease in colonic cell proliferation compared with wild-type and homozygous mice

cellular

abnormal enterocyte proliferation ( J:186265 )

• mice fed a diet lacking arachidonic acid exhibit an intermediate decrease in colonic cell proliferation compared with wild-type and homozygous mice