Phenotypes Associated with This Genotype

Genotype
MGI:5433094

• Allelic Composition: Shh^tm1Chg/Shh^tm1Chg; Tmem107^schlei/Tmem107^schlei
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal floor plate morphology ( J:186552 )

• absence of ventral cell types (V3) in the floor plate

• however, ventral neuron specification defects of V2 interneurons and motor neurons observed in Smo^bnb homozygotes is partially rescued

exencephaly ( J:186552 )

limbs/digits/tail

limbs/digits/tail phenotype ( J:186552 )

N • increased apoptosis observed in the limb bud of Smo^bnb homozygotes is rescued

oligodactyly ( J:186552 )

• reduced digit number observed in Smo^bnb homozygotes is rescued to four or five digits

embryo

abnormal floor plate morphology ( J:186552 )

• absence of ventral cell types (V3) in the floor plate

• however, ventral neuron specification defects of V2 interneurons and motor neurons observed in Smo^bnb homozygotes is partially rescued