Phenotypes Associated with This Genotype

Genotype
MGI:5433632

• Allelic Composition: Aplnr^tm1Dgen/Aplnr^tm1Dgen
• Genetic Background: involves: 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:186909 )

• fewer than expected are found at weaning

behavior/neurological

decreased fluid intake ( J:186909 )

• decreased water intake over a 24 h period

renal/urinary system

decreased urine osmolality ( J:186909 )

• following water deprivation urine osmolality is not increased unlike in wild-type mice

• however, under normal conditions osmolality is similar to controls

• desmopressin induced increase in osmolality is significantly attenuated compared to controls

abnormal urination ( J:186909 )

• following water deprivation urine volume is not decreased unlike in wild-type mice

• however, spontaneously voided urine volume under normal conditions is similar to controls

growth/size/body

decreased body weight ( J:186909 )

• in survivors

homeostasis/metabolism

decreased urine osmolality ( J:186909 )

• following water deprivation urine osmolality is not increased unlike in wild-type mice

• however, under normal conditions osmolality is similar to controls

• desmopressin induced increase in osmolality is significantly attenuated compared to controls