Phenotypes Associated with This Genotype

Genotype
MGI:5438277

• Allelic Composition: Idh1^tm1Mak/Idh1^tm1Mak; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/10 * CBA/Ca

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:186700 )

N • mice exhibit normal hematopoietical parameters in peripheral blood and normal bone marrow cell numbers

abnormal common myeloid progenitor cell morphology ( J:186700 )

• increase in common lymphocyte progenitor cells in the bone marrow and spleen

abnormal common lymphocyte progenitor cell morphology ( J:186700 )

• increase in megakaryocyte-erythroid progenitors in the spleen

increased hematopoietic stem cell number ( J:186700 )

• increase in LSK and lineage-restricted progenitors in the bone marrow and spleen

• increase in LK in the spleen