Phenotypes Associated with This Genotype

Genotype
MGI:5439276

• Allelic Composition: Pacsin1^{Gt(OST287788)Lex}/Pacsin1^{Gt(OST287788)Lex}
• Genetic Background: B6.129S5-Pacsin1^{Gt(OST287788)Lex}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:187784 )

N • mice show normal numbers of cells in the thymus, spleen, and bone marrow and normal levels of dendritic cells and plasmacytoid dendritic cells

decreased circulating interferon-alpha level ( J:187784 )

• mice produce less IFN-alpha during herpes simplex virus I infection than wild-type mice, however IL-6 production was similar to wild-type; both wild-type and mutant mice do not show signs of sickness during infection, indicating ability to clear the virus

abnormal plasmacytoid dendritic cell physiology ( J:187784 )

• plasmacytoid dendritic cells stimulated with cytosine guanine dinucleotide or with influenza virus, vesicular stomatitis virus or herpes simplex virus I produce less IFN-alpha than wild-type plasmacytoid dendritic cells

decreased interferon-alpha secretion ( J:187784 )

• plasmacytoid dendritic cells stimulated with cytosine guanine dinucleotide or with influenza virus, vesicular stomatitis virus or herpes simplex virus produce less IFN-alpha than wild-type plasmacytoid dendritic cells

• production of IL-6 and TNF-alpha in response to stimulation with cytosine guanine dinucleotide are normal

homeostasis/metabolism

decreased circulating interferon-alpha level ( J:187784 )

• mice produce less IFN-alpha during herpes simplex virus I infection than wild-type mice, however IL-6 production was similar to wild-type; both wild-type and mutant mice do not show signs of sickness during infection, indicating ability to clear the virus