Phenotypes Associated with This Genotype

Genotype
MGI:5443876

• Allelic Composition: Tcap^tm1Rnk/Tcap^tm1Rnk
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:188832 )

N • under normal conditions, mice exhibit no abnormal cardiac phenotype

cardiac hypertrophy ( J:188832 )

• increased after transverse aortic constriction

cardiac fibrosis ( J:188832 )

• increased after transverse aortic constriction

increased cardiomyocyte apoptosis ( J:188832 )

• after transverse aortic constriction

increased response of heart to induced stress ( J:188832 )

• after transverse aortic constriction, mice exhibit increased cardiac hypertrophy, fibrosis and apoptosis and severe heart failure compared with wild-type mice

congestive heart failure ( J:188832 )

• severe after transverse aortic constriction

cellular

increased cardiomyocyte apoptosis ( J:188832 )

• after transverse aortic constriction

homeostasis/metabolism

increased response of heart to induced stress ( J:188832 )

• after transverse aortic constriction, mice exhibit increased cardiac hypertrophy, fibrosis and apoptosis and severe heart failure compared with wild-type mice

muscle

increased cardiomyocyte apoptosis ( J:188832 )

• after transverse aortic constriction

abnormal sarcomere morphology ( J:188832 )

• after removal of actin from cardiac sarcomeres, titin N-terminal anchorage is compromised

• however, Z-disks are normal

growth/size/body

cardiac hypertrophy ( J:188832 )

• increased after transverse aortic constriction