Phenotypes Associated with This Genotype

Genotype
MGI:5444174

• Allelic Composition: Pi4ka^tm1.1Arte/Pi4ka^tm1.1Arte; Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte}/Gt(ROSA)26Sor⁺
• Genetic Background: involves: C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:188779 )

• within days of tamoxifen-induction

digestive/alimentary system

abnormal digestive system morphology ( J:188779 )

• following tamoxifen-induction, mucosal epithelial cells of the mucosae of the stomach and the small and large intestines exhibit widespread degeneration and necrosis compared with control mice

abnormal intestine morphology ( J:188779 )

• distended and filled with yellowish clear fluid following tamoxifen-induction

abnormal cecum morphology ( J:188779 )

• following tamoxifen-induction, mice exhibit mucosal epithelial degeneration of cecal mucosa compared with control mice

abnormal duodenum morphology ( J:188779 )

• following tamoxifen-induction, mice exhibit mucosal epithelial degeneration of duodenal mucosa compared with control mice

abnormal stomach mucosa morphology ( J:188779 )

• following tamoxifen-induction, mice exhibit ulceration of nonglandular mucosa and parietal cell degeneration of glandular mucosa compared with control mice

abnormal gastric parietal cell morphology ( J:188779 )

• parietal cell degeneration of glandular mucosa following tamoxifen-induction

distended stomach ( J:188779 )

• distended and filled with food following tamoxifen-induction

endocrine/exocrine glands

abnormal gastric parietal cell morphology ( J:188779 )

• parietal cell degeneration of glandular mucosa following tamoxifen-induction