Phenotypes Associated with This Genotype

Genotype
MGI:5444175

• Allelic Composition: Pi4ka^tm2.1Arte/Pi4ka^tm2.1Arte; Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte}/Gt(ROSA)26Sor⁺
• Genetic Background: involves: C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:188779 )

• within 10 to 11 days of tamoxifen-induction

digestive/alimentary system

abnormal digestive system morphology ( J:188779 )

• following tamoxifen-induction, mice exhibit widespread mucosal epithelial degeneration more so in the small and large intestines and less in the stomach compared with control mice

• however, mice do not exhibit a distended intestine morphology

diarrhea ( J:188779 )

• following tamoxifen-induction

abnormal small intestine crypts of Lieberkuhn morphology ( J:188779 )

• focal atypical hyperplasia of mucosal crypts with small clusters of enlarged atypical crypts lined by tall dysplastic basophilic epithelial cells in the small intestine following tamoxifen-induction

abnormal large intestine morphology ( J:188779 )

• following tamoxifen-induction, mice exhibit swollen and basophilic surface epithelial cells in the large intestine compared with control mice

abnormal large intestine crypts of Lieberkuhn morphology ( J:188779 )

• loss of mucosal crypts in some areas of the large intestine following tamoxifen-induction

abnormal small intestinal villus morphology ( J:188779 )

• following tamoxifen-induction, mice exhibit swollen villous epithelial cells with excessive vacuoles in the small intestine compared with control mice

abnormal digestion ( J:188779 )

• following tamoxifen-induction, mice exhibit loose or discolored intestine content

growth/size/body

decreased body size ( J:188779 )

• thin following tamoxifen-treatment

behavior/neurological

unresponsive to tactile stimuli ( J:188779 )

• in moribund mice following tamoxifen-induction

hunched posture ( J:188779 )

• following tamoxifen-treatment

integument

abnormal coat appearance ( J:188779 )

• poor coat condition following tamoxifen-treatment

endocrine/exocrine glands

abnormal large intestine crypts of Lieberkuhn morphology ( J:188779 )

• loss of mucosal crypts in some areas of the large intestine following tamoxifen-induction

abnormal small intestine crypts of Lieberkuhn morphology ( J:188779 )

• focal atypical hyperplasia of mucosal crypts with small clusters of enlarged atypical crypts lined by tall dysplastic basophilic epithelial cells in the small intestine following tamoxifen-induction