Phenotypes Associated with This Genotype

Genotype
MGI:5444881

• Allelic Composition: 1700016L21Rik^{Tg(Itgax-HBEGF/EGFP)57Lan}/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased leukocyte cell number ( J:193548 )

• in the skin of diphtheria toxin- and IMQ-treated mice

decreased neutrophil cell number ( J:193548 )

• in the skin of diphtheria toxin- and IMQ-treated mice

decreased T cell number ( J:193548 )

• decreased alpha-beta T cells in the skin of diphtheria toxin- and IMQ-treated mice

decreased gamma-delta T cell number ( J:193548 )

• in the skin of diphtheria toxin- and IMQ-treated mice

decreased interleukin-17 secretion ( J:193548 )

• in diphtheria toxin- and IMQ-treated mice

abnormal response to infection ( J:189122 )

• despite normal monocyte numbers in the blood, LPS-treated mice fail to exhibit an accumulation of CD11c+MHCII+DC-SIGN/CD209+CD14+ cells in the skin lymph nodes unlike wild-type mice

decreased susceptibility to bacterial infection ( J:210086 )

• mice treated with antibiotic, then diphtheria toxin (DTR) and infected with non-invasive Salmonella exhibit decreased bacterial titers in the mesenteric lymph nodes as compared to DTR-untreated controls

hematopoietic system

decreased leukocyte cell number ( J:193548 )

• in the skin of diphtheria toxin- and IMQ-treated mice

decreased neutrophil cell number ( J:193548 )

• in the skin of diphtheria toxin- and IMQ-treated mice

decreased T cell number ( J:193548 )

• decreased alpha-beta T cells in the skin of diphtheria toxin- and IMQ-treated mice

decreased gamma-delta T cell number ( J:193548 )

• in the skin of diphtheria toxin- and IMQ-treated mice

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:193548 )

• mice treated with diphtheria toxin and IMQ are protected from psoriasis development with decreased ear swelling and numbers of leukocytes, neutrophils and gamma-delta and alpha-beta T cells in the skin compared with wild-type mice