Phenotypes Associated with This Genotype

Genotype
MGI:5445109

• Allelic Composition: St3gal4^tm1.1Jxm/St3gal4^tm1.1Jxm; St3gal6^tm1.1Jxm/St3gal6^tm1.1Jxm
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal leukocyte migration ( J:189086 )

• impaired lymphocyte homing into lymph nodes and Peyer's patches

impaired leukocyte tethering or rolling ( J:189086 )

• impaired P- and E-selectin-dependent rolling under dynamic flow conditions, more so than in St3gal6^tm1.1Jxm homozygotes

• impaired P- and E-selectin-dependent rolling during inflammation in vivo

decreased lymphocyte cell number ( J:189086 )

• reduced lymphocytes in the abdominal, celiac, mesenteric and inguinal lymph nodes and Peyer's patch

• however, the number of lymphocytes in the spleen, thymus and bone marrow is normal

increased leukocyte cell number ( J:189086 )

increased neutrophil cell number ( J:189086 )

impaired neutrophil recruitment ( J:189086 )

• impaired neutrophil recruitment into inflamed peritoneum after injection of thioglycollate, more so than in St3gal6^tm1.1Jxm homozygotes

hematopoietic system

hematopoietic system phenotype ( J:189086 )

N • mice exhibit normal numbers of red blood cells and recruitment of monocytes

abnormal leukocyte migration ( J:189086 )

• impaired lymphocyte homing into lymph nodes and Peyer's patches

impaired leukocyte tethering or rolling ( J:189086 )

• impaired P- and E-selectin-dependent rolling under dynamic flow conditions, more so than in St3gal6^tm1.1Jxm homozygotes

• impaired P- and E-selectin-dependent rolling during inflammation in vivo

thrombocytopenia ( J:189086 )

• more so than in St3gal4^tm1.1Jxm homozygotes

increased mean platelet volume ( J:189086 )

• more so than in St3gal4^tm1.1Jxm homozygotes

decreased lymphocyte cell number ( J:189086 )

• reduced lymphocytes in the abdominal, celiac, mesenteric and inguinal lymph nodes and Peyer's patch

• however, the number of lymphocytes in the spleen, thymus and bone marrow is normal

increased leukocyte cell number ( J:189086 )

increased neutrophil cell number ( J:189086 )

impaired neutrophil recruitment ( J:189086 )

• impaired neutrophil recruitment into inflamed peritoneum after injection of thioglycollate, more so than in St3gal6^tm1.1Jxm homozygotes

cellular

abnormal leukocyte migration ( J:189086 )

• impaired lymphocyte homing into lymph nodes and Peyer's patches

impaired leukocyte tethering or rolling ( J:189086 )

• impaired P- and E-selectin-dependent rolling under dynamic flow conditions, more so than in St3gal6^tm1.1Jxm homozygotes

• impaired P- and E-selectin-dependent rolling during inflammation in vivo