Phenotypes Associated with This Genotype

Genotype
MGI:5445375

• Allelic Composition: Cyp4f14^tm1Rspk/Cyp4f14^tm1Rspk
• Genetic Background: involves: 129S/SvEv * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal enzyme/coenzyme level ( J:188849 )

• mice fed a gammaT-165 diet (high tocopherol composition) exhibit a 2-fold increased concentrations of gamma-tocopherol in plasma and tissues compared with wild-type mice

• mice fed a gammaT-10 diet (low tocopherol composition) exhibit a 2-fold increase in liver gamma-tocopherol concentrations compared with wild-type mice

abnormal urine homeostasis ( J:188849 )

• mice fed either a gammaT-10 diet (low tocopherol composition) or gammaT-165 diet (high tocopherol composition) exhibit reduced alpha-, delta- and gamma-tocopherol metabolites in the urine compared with wild-type mice

abnormal enzyme/coenzyme activity ( J:188849 )

• mice fed a gammaT-10 diet (low tocopherol composition) exhibit reduced hepatic microsomal vitamin E-omega-hydroxylase activity compared with wild-type mice

renal/urinary system

abnormal urine homeostasis ( J:188849 )

• mice fed either a gammaT-10 diet (low tocopherol composition) or gammaT-165 diet (high tocopherol composition) exhibit reduced alpha-, delta- and gamma-tocopherol metabolites in the urine compared with wild-type mice

digestive/alimentary system

abnormal feces composition ( J:188849 )

• mice fed a gammaT-165 diet (high tocopherol composition) exhibit reduced levels of all omega-oxidation metabolites of gamma-tocopherol and many delta-tocopherol metabolites in the feces compared with wild-type mice

• mice fed a gammaT-165 diet (high tocopherol composition) exhibit reduced levels of 24-hr omega-oxidation metabolites of alpha-, delta- and gamma-tocopherol metabolites in the feces compared with wild-type mice

• mice fed a gammaT-10 diet (low tocopherol composition) exhibit reduced levels of delta- and omega-oxidation metabolites of gamma-tocopherol in the feces compared with wild-type mice

• mice fed a gammaT-165 diet (high tocopherol composition) excrete novel omega-1- and omega-2-hydroxylation products of gamma- and delta-tocopherol compared with wild-type mice

• mice fed a gammaT-165 diet (high tocopherol composition) excrete increased levels of parent tocopherols compared with wild-type mice