Analysis Tools
renal/urinary system
albuminuria
(
J:188500
)
|
• on a predominantly C57BL/6 background, many mice develop albuminuria by 8 weeks of age
• however, some mice that retain Myo1e expression in podocytes, as confirmed by immunostaining, do not exhibit albuminuria; a number of these maintain normal urinary protein excretion up to 6-8 months of age
|
|
• by 4 months of age, the average number of foot processes per unit length of the basement membrane is lower than that in controls
|
|
• at 2 months of age, proteinuric mice exhibit only a few areas of foot process effacement
• by 4 months of age, pronounced foot process effacement is observed, unlike in control mice
|
|
• by 4 months of age, the overall outline of the GBM appears jagged and uneven, unlike in control mice
|
|
• at 2 months of age, proteinuric mice exhibit only a few areas of GBM thickening
• by 4 months of age, average GBM thickness is increased relative to that in controls
|
|
• at 8 months of age, mice exhibit some sclerotic glomeruli, unlike control mice
• however, no glomerulosclerosis is seen at 4 months
|
renal cast
(
J:188500
)
|
• at 8 months of age, mice exhibit a few proteinaceous casts, unlike control mice
• however, no renal casts are seen at 4 months
|
homeostasis/metabolism
albuminuria
(
J:188500
)
|
• on a predominantly C57BL/6 background, many mice develop albuminuria by 8 weeks of age
• however, some mice that retain Myo1e expression in podocytes, as confirmed by immunostaining, do not exhibit albuminuria; a number of these maintain normal urinary protein excretion up to 6-8 months of age
|
