Phenotypes Associated with This Genotype

Genotype
MGI:5445942

• Allelic Composition: Myo1e^tm1Flv/Myo1e^tm1.1Flv; Tg(NPHS2-cre)295Lbh/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

albuminuria ( J:188500 )

• on a predominantly C57BL/6 background, mice develop moderate albuminuria by 8 weeks of age, while control mice show no evidence of albuminuria up to 6 months of age

• however, at 2-6 months of age, mice exhibit significantly lower albumin:creatinine ratios than those observed in Myo1e^tm1.1Flv homozygotes

glomerulosclerosis ( J:188500 )

• at 7 months of age, mice exhibit some sclerotic glomeruli, unlike control mice

renal cast ( J:188500 )

• at 7 months of age, mice exhibit a few proteinaceous casts, unlike control mice

homeostasis/metabolism

albuminuria ( J:188500 )

• on a predominantly C57BL/6 background, mice develop moderate albuminuria by 8 weeks of age, while control mice show no evidence of albuminuria up to 6 months of age

• however, at 2-6 months of age, mice exhibit significantly lower albumin:creatinine ratios than those observed in Myo1e^tm1.1Flv homozygotes