Phenotypes Associated with This Genotype

Genotype
MGI:5446444

• Allelic Composition: Gpr89^tm1.1Ymae/Gpr89^tm1.1Ymae; Tg(KRT5-cre)1Tak/0
• Genetic Background: involves: C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:189574 )

• half of mice die within 1 month

reproductive system

abnormal reproductive system development ( J:189574 )

• impaired development of external genitalia

integument

enlarged sebaceous gland ( J:189574 )

• at 1 month

impaired skin barrier function ( J:189574 )

• 4-fold increase in transepidermal water loss at P5

dermatitis ( J:189574 )

• at 1 month, inflammatory cells containing melanin with enlarged sebaceous glands are observed in the dermis

alopecia ( J:189574 )

• associated with scaly skin

abnormal hair follicle morphology ( J:189574 )

abnormal epidermis stratum basale morphology ( J:189574 )

• ballooning basal cells

• intracellular vacuoles and intracytoplasmic droplets in the basal layer

abnormal epidermis stratum corneum morphology ( J:189574 )

• abnormal formation of lamellar structures between corneum layers

• abnormal and decreased formation of contents of lamellar granules

hyperkeratosis ( J:189574 )

• in newborn mice but not at P5

abnormal keratinocyte morphology ( J:189574 )

• aberrant lamellar granules

scaly skin ( J:189574 )

• apparent 1 week after birth

abnormal skin development ( J:189574 )

• impaired

growth/size/body

abnormal ear lobe morphology ( J:189574 )

• impaired development

decreased body weight ( J:189574 )

postnatal growth retardation ( J:189574 )

hearing/vestibular/ear

abnormal ear lobe morphology ( J:189574 )

• impaired development

homeostasis/metabolism

impaired skin barrier function ( J:189574 )

• 4-fold increase in transepidermal water loss at P5

pigmentation

hypopigmentation ( J:189574 )

• apparent 4 days after birth

craniofacial

abnormal ear lobe morphology ( J:189574 )

• impaired development

endocrine/exocrine glands

enlarged sebaceous gland ( J:189574 )

• at 1 month

immune system

dermatitis ( J:189574 )

• at 1 month, inflammatory cells containing melanin with enlarged sebaceous glands are observed in the dermis