Phenotypes Associated with This Genotype

Genotype
MGI:5447539

• Allelic Composition: Nr3c1^tm1.1Jda/Nr3c1^tm1.1Jda; Tg(Lck-cre)548Jxm/0
• Genetic Background: B6.Cg-Nr3c1^tm1.1Jda Tg(Lck-cre)548Jxm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased thymocyte apoptosis ( J:189951 )

• double positive thymocytes are resistant to glucocorticoid-induced apoptosis compared with wild-type cells

thymus hypoplasia ( J:189951 )

decreased double-positive T cell number ( J:189951 )

• in the thymus

decreased CD4-positive, alpha-beta T cell number ( J:189951 )

• modestly in the periphery

• in the thymus

decreased CD8-positive, alpha-beta T cell number ( J:189951 )

• modestly in the periphery

• in the thymus

decreased single-positive T cell number ( J:189951 )

• of mature single positive cells in the thymus

abnormal humoral immune response ( J:189951 )

• polyclonal T cells exhibit attenuated response to an antigen compared with wild-type cells

cellular

decreased thymocyte apoptosis ( J:189951 )

• double positive thymocytes are resistant to glucocorticoid-induced apoptosis compared with wild-type cells

hematopoietic system

decreased thymocyte apoptosis ( J:189951 )

• double positive thymocytes are resistant to glucocorticoid-induced apoptosis compared with wild-type cells

thymus hypoplasia ( J:189951 )

decreased double-positive T cell number ( J:189951 )

• in the thymus

decreased CD4-positive, alpha-beta T cell number ( J:189951 )

• modestly in the periphery

• in the thymus

decreased CD8-positive, alpha-beta T cell number ( J:189951 )

• modestly in the periphery

• in the thymus

decreased single-positive T cell number ( J:189951 )

• of mature single positive cells in the thymus

endocrine/exocrine glands

decreased thymocyte apoptosis ( J:189951 )

• double positive thymocytes are resistant to glucocorticoid-induced apoptosis compared with wild-type cells

thymus hypoplasia ( J:189951 )