Phenotypes Associated with This Genotype

Genotype
MGI:5463446

• Allelic Composition: Kif19a^tm1Noh/Kif19a^tm1Noh
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:191072 )

• born at the expected Mendelian ratio but few survivors at 4 weeks of age

reproductive system

abnormal oviduct morphology ( J:191072 )

♀ • lumens are filled with mucus and debris

♀ • debris contains nuclear structures suggesting it is made up of dead cells

abnormal oviduct epithelium motile cilium morphology ( J:191072 )

♀ • a 2.5 fold increase in cilia length

abnormal female reproductive system physiology ( J:191072 )

♀ • movement of oviduct ciliary tips is abnormal, disorganized, and fails to generate proper fluid flow

female infertility ( J:191072 )

♀ • apparently caused by fallopian tube obstruction

nervous system

increased brain ependyma motile cilium length ( J:191072 )

• a 1.8 fold increase in cilia length

hydrocephaly ( J:191072 )

• in males and females

respiratory system

abnormal respiratory motile cilium morphology ( J:191072 )

• a 1.4 fold increase in cilia length in the trachea

abnormal tracheal ciliated epithelium morphology ( J:191072 )

• a 1.4 fold increase in cilia length

growth/size/body

postnatal growth retardation ( J:191072 )

cellular

increased brain ependyma motile cilium length ( J:191072 )

• a 1.8 fold increase in cilia length

abnormal oviduct epithelium motile cilium morphology ( J:191072 )

♀ • a 2.5 fold increase in cilia length

abnormal respiratory motile cilium morphology ( J:191072 )

• a 1.4 fold increase in cilia length in the trachea