Phenotypes Associated with This Genotype

Genotype
MGI:5463665

• Allelic Composition: Arih2^tm1Mak/Arih2^tm1Mak
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:191066 )

• Background Sensitivity: on a mixed 129P2/OlaHsd and C57BL/6 background pups are born alive but most die in the first week of life with only 3.3% surviving at 3 weeks of age, in contrast on an inbred C57BL/6 background no live births are seen

immune system

increased inflammatory response ( J:191066 )

• survivors display overt inflammatory phenotypes

• infiltration of T cells, macrophages, granulocytes and dendritic cells in various organs, including liver, lung and heart

heart inflammation ( J:191066 )

• infiltration of T cells, macrophages, granulocytes and dendritic cells

liver inflammation ( J:191066 )

• infiltration of T cells, macrophages, granulocytes and dendritic cells

lung inflammation ( J:191066 )

• infiltration of T cells, macrophages, granulocytes and dendritic cells

dermatitis ( J:191066 )

• debilitating dermatitis is seen in survivors

growth/size/body

decreased body size ( J:191066 )

• survivors are severely runted

cachexia ( J:191066 )

integument

dermatitis ( J:191066 )

• debilitating dermatitis is seen in survivors

liver/biliary system

liver inflammation ( J:191066 )

• infiltration of T cells, macrophages, granulocytes and dendritic cells

cardiovascular system

heart inflammation ( J:191066 )

• infiltration of T cells, macrophages, granulocytes and dendritic cells

respiratory system

lung inflammation ( J:191066 )

• infiltration of T cells, macrophages, granulocytes and dendritic cells