Phenotypes Associated with This Genotype

Genotype
MGI:5463666

• Allelic Composition: Arih2^tm1Mak/Arih2^tm1Mak
• Genetic Background: B6.129P2-Arih2^tm1Mak

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:191066 )

• Background Sensitivity: on an inbred C57BL/6 background mice die at E16.5, unlike mice on a mixed 129P2/OlaHsd and C57BL/6 background that display postnatal lethality

immune system

abnormal dendritic cell physiology ( J:191066 )

• dendritic cells spuriously and spontaneously activate in culture

increased inflammatory response ( J:191066 )

• when hematopoietic progenitor cells are transferred into lethally irradiated Rag1^tm1Mom mice, the mice develop a spontaneous lethal inflammation

liver/biliary system

liver hypoplasia ( J:191066 )

abnormal liver physiology ( J:191066 )

• abundant apoptosis is detected in the liver at E16.5

• however, the hematopoietic progenitor compartment of the fetal liver is relatively unaffected

cellular

increased apoptosis ( J:191066 )

• abundant apoptosis is detected in the liver at E16.5