Phenotypes Associated with This Genotype

Genotype
MGI:5463906

• Allelic Composition: Nfe2l2^tm1.1Sred/Nfe2l2^tm1.1Sred; Tg(Scgb1a1-cre)1Grau/0
• Genetic Background: involves: C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased interleukin-1 beta secretion ( J:191916 )

• 2-fold in the bronchoalveolar lavage fluid under normal conditions

decreased tumor necrosis factor secretion ( J:191916 )

• in the bronchoalveolar lavage fluid under hypoxic conditions

homeostasis/metabolism

increased susceptibility to injury ( J:191916 )

• mice exhibit higher levels of hyperoxic lung injury with increased protein and cells (macrophage and epithelial cells) in the bronchoalveolar lavage fluid and increased cell death in lung parenchyma compared with control mice

• 72 hours after oxidant exposure, mice exhibit persistent cellular accumulation and proteinaceous edema in alveolar spaces in the lungs unlike in control mice

cellular

abnormal cell death ( J:191916 )

• under hyperoxic conditions, lung parenchyma exhibits a 6-fold increase in cell death compared with control cells