Phenotypes Associated with This Genotype

Genotype
MGI:5467384

• Allelic Composition: Casp1^tm1Flv/Casp1^tm1Flv; Casp4^del/Casp4^del
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

decreased incidence of tumors by chemical induction ( J:191239 )

• mice treated with 7,12-Dimethylbenz(a)anthracene/12-O-Tetradecanoylphorbol-13-acetate (DMBA) exhibit later onset and a lower incidence of tumors compared with type mice

integument

integument phenotype ( J:191239 )

N • untreated or TPA, TNF or EGF-treated keratinocytes exhibit normal proliferation

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:191239 )

• mice treated with 7,12-Dimethylbenz(a)anthracene/12-O-Tetradecanoylphorbol-13-acetate (DMBA) exhibit later onset and a lower incidence of tumors compared with type mice