Phenotypes Associated with This Genotype

Genotype
MGI:5467728

• Allelic Composition: Slc6a4^tm1Kpl/Slc6a4⁺
• Genetic Background: B6.129-Slc6a4^tm1Kpl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal social investigation ( J:144937 )

• 8 week old females show a trend towards decreased preference for interacting with a stimulus mouse in a social approach assay, however this does not reach significance

• while 8 week old males do not show a change in preference for social interaction for the first trial, upon reexposure to the same social target in trial 2, males do not show attenuation of preference for social investigation between the first and second trials as seen in wild-type mice, indicating impaired social recognition in male

nervous system

increased brain weight ( J:144937 )

growth/size/body

megacephaly ( J:144937 )