Phenotypes Associated with This Genotype

Genotype
MGI:5470091

• Allelic Composition: Pfn1^tm1Foxp/Pfn1^tm1Foxp; Tg(Tek-cre)1Ywa/0
• Genetic Background: involves: C57BL/6 * C57BL/6NTac * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal vascular endothelial cell migration ( J:193938 )

• endothelial cell planar migration stimulated by VEGF-A is inhibited compared with control cells

cardiovascular system

decreased angiogenesis ( J:193938 )

• angiogenesis after ischemia or skin punch is impaired

• however, mice exhibit normal developmental angiogenesis

abnormal vascular endothelial cell migration ( J:193938 )

• endothelial cell planar migration stimulated by VEGF-A is inhibited compared with control cells

abnormal vascular wound healing ( J:193938 )

• after skin punch, mice exhibit fewer microvessels within the healing wound and larger blood vessels in the region surrounding the injury compared with control mice

homeostasis/metabolism

abnormal vascular wound healing ( J:193938 )

• after skin punch, mice exhibit fewer microvessels within the healing wound and larger blood vessels in the region surrounding the injury compared with control mice

delayed wound healing ( J:193938 )

• after skin punch