Phenotypes Associated with This Genotype

Genotype
MGI:5471120

• Allelic Composition: Vegfa^tm2Gne/Vegfa^tm2Gne; Tg(Tnnt2-cre)5Blh/0
• Genetic Background: involves: 129/Sv * C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:193198 )

• complete lethality is observed after E15.5

growth/size/body

decreased body size ( J:193198 )

• at E15.5, mutants are runted

cardiovascular system

cardiovascular system phenotype ( J:193198 )

N

abnormal angiogenesis ( J:193198 )

• at E12.5, the peritruncal area and ventricular septum lack angiogenic sprouts or coronary plexuses that are observed in controls

myocardium necrosis ( J:193198 )

abnormal coronary vessel morphology ( J:193198 )

abnormal coronary artery morphology ( J:193198 )

• by E14.5, mutants have only a few immature myocardial coronary arteries

abnormal coronary vein morphology ( J:193198 )

• dilated subepicardial veins at E14.5

abnormal heart septum morphology ( J:193198 )

• at E15.5, mutants have necrotic or ruptured septa

thin ventricular wall ( J:193198 )

heart hemorrhage ( J:193198 )

• at E15.5, mutants display cardiac hemorrhages

muscle

myocardium necrosis ( J:193198 )