Phenotypes Associated with This Genotype

Genotype
MGI:5471654

• Allelic Composition: Gnai3^tm1Lbi/Gnai3^tm1Lbi
• Genetic Background: involves: 129S/SvEv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Fusion of lumbar vertebrae in Gnai3^tm1Lbi/Gnai3^tm1Lbi mice

skeleton

abnormal sternocostal joint morphology ( J:193170 )

• one mouse has the eighth rib ectopically attached to the sternum

abnormal rib morphology ( J:193170 )

• a single mouse lacking rib fusions had small triangular outgrowths of cartilage at the distal end of the second rib pair

rib fusion ( J:193170 )

• Background Sensitivity: fusions of the cartilaginous portion of the distal ribs are seen in 95% of mice on a 129S/SvEv background but in less than 40% of mice on a mixed 129S/SvEv and C57BL/6 background

• Background Sensitivity: the average number of fusions is reduced in mice on a mixed 129S/SvEv and C57BL/6 background compared to mice on a 129S/SvEv background

• fusions typically involve only ribs that articulate with the sternum

• ectopic connection of the eighth rib to the sternum is seen in 1 case

• fusions are detected as early as E14.5

abnormal lumbar vertebrae morphology ( J:193170 )

• Background Sensitivity: incidence of lumbar defects in reduced in mice on a mixed 129S/SvEv and C57BL/6 background compared to mice on a 129S/SvEv background

• deformation or partial fusion of one or more vertebral bodies in 9 of 10 mice in the lumbar region

• in 2 of 10 pups pointed outgrowths that do not fuse are detected

lumbar vertebral fusion ( J:193170 )

• in 7 of 10 pups a small bridge of bone connecting the bodies of two or three adjacent vertebrae is present