Phenotypes Associated with This Genotype

Genotype
MGI:5471655

• Allelic Composition: Gnai1^tm1Drs/Gnai1⁺; Gnai3^tm1Lbi/Gnai3^tm1Lbi
• Genetic Background: involves: 129S/SvEv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Rib and sternum defects in mice with mutations of Gnai1, Gnai2, and/or Gnai3

skeleton

sternebra fusion ( J:193170 )

rib fusion ( J:193170 )

• rib fusions are more frequent and severe compared to mice homozygous for Gnai3^tm1Lbi alone

• rib fusions frequently involve both true and false ribs

lumbar vertebral fusion ( J:193170 )

• not noticeably more severe than in mice homozygous for Gnai3^tm1Lbi alone