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Phenotypes Associated with This Genotype
Genotype
MGI:5471656
Allelic
Composition		 Gnai2tm1Lbi/Gnai2+
Gnai3tm1Lbi/Gnai3tm1Lbi
Genetic
Background		 involves: 129S/SvEv * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnai2tm1Lbi mutation (1 available); any Gnai2 mutation (56 available)
Gnai3tm1Lbi mutation (1 available); any Gnai3 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Rib and sternum defects in mice with mutations of Gnai1, Gnai2, and/or Gnai3

skeleton
abnormal sternocostal joint morphology ( J:193170 )
• one mouse has the eighth rib ectopically attached to the sternum
rib fusion ( J:193170 )
• rib fusions are similar in severity to mice homozygous for Gnai3tm1Lbi and Gnai1tm1Drs

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory