Phenotypes Associated with This Genotype

Genotype
MGI:5472016

• Allelic Composition: Gt(ROSA)26Sor^{tm1(RICTOR)Jger}/Gt(ROSA)26Sor^{tm1(RICTOR)Jger}; Tg(GFAP-cre)25Mes/0; Tg(GFAP-EGFR*,-lacZ)#Agu/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Increased grade of oligodendroglioma in Gt(ROSA)26Sor^{tm1(RICTOR)Jger}/Gt(ROSA)26Sor^{tm1(RICTOR)Jger} Tg(GFAP-EGFR*,-lacZ)#Agu/0 Tg(GFAP-cre)25Mes/0 mice

mortality/aging

premature death ( J:192206 )

• all mice succumb to gliomas by 18 weeks

neoplasm

increased glioma incidence ( J:192206 )

• mice exhibit accelerated glioma development compared with Gt(ROSA)26Sor^{tm1(RICTOR)Jger}/Gt(ROSA)26Sor^{tm1(RICTOR)Jger} Tg(GFAP-cre)25Mes mice

increased astrocytoma incidence ( J:192206 )

• mixed astrocytic-oligodendroglial tumors

increased oligodendroglioma incidence ( J:192206 )

• mixed astrocytic-oligodendroglial tumors

decreased tumor latency ( J:192206 )

• mice exhibit accelerated glioma development compared with Gt(ROSA)26Sor^{tm1(RICTOR)Jger}/Gt(ROSA)26Sor^{tm1(RICTOR)Jger} Tg(GFAP-cre)25Mes mice

nervous system

increased glioma incidence ( J:192206 )

• mice exhibit accelerated glioma development compared with Gt(ROSA)26Sor^{tm1(RICTOR)Jger}/Gt(ROSA)26Sor^{tm1(RICTOR)Jger} Tg(GFAP-cre)25Mes mice

increased astrocytoma incidence ( J:192206 )

• mixed astrocytic-oligodendroglial tumors

increased oligodendroglioma incidence ( J:192206 )

• mixed astrocytic-oligodendroglial tumors

abnormal postnatal subventricular zone morphology ( J:192206 )

• 3-fold increase in thickness