Phenotypes Associated with This Genotype

Genotype
MGI:5474625

• Allelic Composition: Gnai2^tm2.1Lbi/Gnai2^tm2.1Lbi; Tg(Cd4-cre)1Cwi/0
• Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6NTac * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

increased susceptibility to induced colitis ( J:194587 )

• lose significantly more weight following dextran sulfate sodium treatment compared to controls

neoplasm

increased incidence of tumors by chemical induction ( J:194587 )

• increased number of colon tumors in mice treated with azoxymethane followed by 3 cycles of dextran sulfate sodium administration compared to controls

• tumors are predominantly distributed in the distal colon and 80% of mice show rectal prolapse

hematopoietic system

decreased T-helper 17 cell number ( J:194587 )

• isolated splenic CD4+ T cells develop significantly fewer T-helper 17 cells under polarizing conditions

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:194587 )

• increased number of colon tumors in mice treated with azoxymethane followed by 3 cycles of dextran sulfate sodium administration compared to controls

• tumors are predominantly distributed in the distal colon and 80% of mice show rectal prolapse

immune system

increased susceptibility to induced colitis ( J:194587 )

• lose significantly more weight following dextran sulfate sodium treatment compared to controls

decreased T-helper 17 cell number ( J:194587 )

• isolated splenic CD4+ T cells develop significantly fewer T-helper 17 cells under polarizing conditions