Phenotypes Associated with This Genotype

Genotype
MGI:5474679

• Allelic Composition: Gabrg2^tm2Spet/Gabrg2⁺; Tg(Camk2a-tTA)1Mmay/0; Tg(tetO-cre)LC1Bjd/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased susceptibility to pharmacologically induced seizures ( J:194736 )

• induced by pentylenetetrazil in mice treated with doxycycline treatment between conception and P21 or not treated with doxycycline at all

• induced by pentylenetetrazil compared with Gabrg2^tm2Spet heterozygotes

• doxycycline treatment between conception and P21 increased the time to first clonic seizure compared with mice not treated with doxycycline

• however, no seizure kindling effect is observed

nervous system

increased susceptibility to pharmacologically induced seizures ( J:194736 )

• induced by pentylenetetrazil in mice treated with doxycycline treatment between conception and P21 or not treated with doxycycline at all

• induced by pentylenetetrazil compared with Gabrg2^tm2Spet heterozygotes

• doxycycline treatment between conception and P21 increased the time to first clonic seizure compared with mice not treated with doxycycline

• however, no seizure kindling effect is observed